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Importantly, mitochondrial dysfunction can induce microglial activation via both extrinsic and intrinsic mechanisms (Figure 2) (235, 254)

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ACS Nano 18:1263912671 Yang L, Dong S, Gai S, Yang D, Ding H, Feng L, Yang G, Rehman Z, Yang P (2024) Deep insight of design, mechanism, and cancer theranostic strategy of nanozymes